Wednesday, 7 November 2007

POISE study results announced

Nov 7 Orlando. The eagerly anticipated POISE study results where presented at the annual meeting  of the American Heart Association. Unexpectedly the results show mixed benefits and risks. In brief, commencing perioperative beta-blockade reduced AMIs, but increased deaths (due to CVA and sepsis). The exact mechanisms behind these findings remain puzzling. In summary, for every 1,000 patients on metoprolol, 15 MIs, 8 new cases of AF and 3 urgent CAGS would be prevented but at the expense of 8 extra deaths, 5 extra strokes and 53 patients with significant hypotension. We await the full paper and the resulting discussion.

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