Tuesday, 29 January 2008

NSAIDS and Cardiovascular safety


This comprehensive review published in Circulation gives a good insight into the problem  of cardiovascular risk and the use of COX 2 inhibitors or conventional NSAIDs. I covers the basic pharmacology as well as the clinical use of this important group of drugs. Importantly it looks at the different CVS risk of the conventional NSAIDs. Diclofenac has a high risk (> 2) while naproxen is low risk. More food for thought when prescribing NSAIDs/COX 2 inhibitors for post-op analgesia

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