Thursday, 26 March 2009

NICE SUGAR not so sweet


26/3/09 NEJM. The NICE SUGAR study of glucose control in ICU patients shows that very tight normogylcaemia (4.5 to 6 mmmol/l) had a worse outcome than looser control of blood glucose (8 to 10 mmol/l). 90 day mortality was 27.5% versus 24.9% respectively. This is in contrast to previous studies from Belgium that showed a marked improvement in survival with normoglycaemia in critically ill patients. The accompanying editorial backgrounds the whole issue well.

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