Tuesday, 21 July 2009

The FDA and Acetaminophen (Paracetamol)


At a meeting on June 30 an FDA advisory panel recommended to
make four changes to Acetaminpohen (paracetamol) use in the USA.
These are based on reducing the risk of hepatic injury (it's the
leading cause of liver failure in the USA).
1. Reducing the maximum daily dose from 4g to a lower dose.
2. Reduce the maximum single dose from 1g to 650mg for OTC use
3. Making the 1g dose prescription only
4. Remove combination products containing paracetamol.

This is likely to cause significant debate, and also concern amongst
the drug companies.

Watch for further developments about this widely used drug

See further info here:
http://www.time.com/time/health/article/0,8599,1908408,00.html?xid=rss-topstories
http://www.fda.gov/AdvisoryCommittees/Calendar/ucm143083.htm

A good review of perioperative use of paracetamol published in Anaesthesia is here
http://www.ncbi.nlm.nih.gov/pubmed/19087009

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