Monday, 30 September 2013

What we don't know about Tranexamic acid ...

Trauma and Tranexamic acid – Editorial . MJA Sept 2013

The CRASH-2 (Clinical Randomisation of an Antifibrinolytic Significant haemorrhage 2) is a landmark study that has changed our practice when dealing with trauma patients. This editorial discusses the gaps in our knowledge with  regards to tranexamic acid  and trauma patients . To address some unknowns  about this topic, a new study PATCH- Trauma ( Pre-hospital Anti- fibrinolytics for traumatic coagulopathy and Haemorrhage study) funded by the NHMRC will start recruiting soon from trauma centres throughout Australia and New Zealand. Westmead will certainly be involved!

1 comment:

  1. Hi Pedram

    The MJA editorial worries about thrombotic events in TxA treated patients, citing figures from the MATTERs study (9xPE, 12xDVT).

    I can't find any reference to these figures in the MATTERs study beyond a paragraph in the discussion where they acknowledge a higher VTE rate but point to their severity of injury profile and survivorship bias as potential reasons (and it's a retrospective study with limitations, as the MJA editorial points out).

    What am I missing? Can you work out where those figures came from?



    (Anaesthetic trainee, UK)