Tuesday, 5 November 2013

Neuroaxial block, death and serious cardiovascular morbidity in the POISE trial. BJA Sept 2013

This post hoc analysis of the POISE trial has discovered an association between epidural combined with GA (versus GA alone) and increased risk of adverse cardiovascular outcomes in patients at high risk of cardiovascular morbidity. The most notable increased risk was shown with thoracic epidurals. Rather than change practice, this article highlights the need for more studies to help guide the patient population that will benefit most from a neuraxial block and those who we may actually harm. An accompanying editorial discusses the limitation of the methodology of propensity-score matching used in the analysis.

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