Tuesday, 26 May 2015

Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomized placebo controlled trials. MJA February 2015.

This systematic review and meta-analysis of 13 RCTs (10 for  osteoarthritis, 3 for back pain) concluded that paracetamol is ineffective in the treatment of low back pain and provides minimal short term benefit for people with osteoarthritis of hips or knees. It also found that patients taking paracetamol are nearly 4 times more likely to have abnormal LFTs results but the clinical importance of this effect is uncertain. Is it time to reconsider the use of paracetamol in back pain and osteoarthritis?

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