Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials. BJA Oct 2015.
This meta-analysis of RCTs investigates the influence of liberal and restrictive blood transfusion strategies on mortality in perioperative (17 trials) and critically ill (10 trials) adult patients. Patients in the perioperative period receiving a liberal transfusion strategy had lower all-cause mortality when compared with a restrictive transfusion strategy. There was no difference in mortality in critically ill patients receiving liberal vs restrictive transfusion strategies. This is the first meta-analysis to focus on the perioperative setting.