Monday, 14 March 2016

Neurodevelopmental outcome at 2 years of age after general anaestehsia and awake-regional anaesthesia in infancy (GAS): an international multicenter, randomised controlled trial. Lancet October 2015.

This is the first randomised controlled trial assessing the effect of general anaestheisa in infancy on neurodevelopmental outcome. This study randomised 363 infants (younger than 60 weeks) to receive awake-regional anaesthesia and 359 to general anaesthesia for inguinal herniorrphaphy. The primary outcome will be WPPSI-III Full Scale Intelligence Quotient score at 5 years (data is yet to be collected). The secondary outcome is reported here a composite cognitive score of Bayley Scales of Infant and Toddler Development III assess at 2 years. There is no difference in the cognitive composite score between the 2 groups at 2 years. The median duration of anaesthsia was 54 minutes. It should be noted that this is an analysis of secondary outcome, and reassessment at 5 years is necessary before definitive conclusions can be drawn.

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